Seacoast Commercial Listings

MLS Number 5046898

• CommercialLease
• Lease 29
• Address 126 Daniel Street
• Square Feet 22,148
• Year Built 1800

Ground-Floor Office Space for Lease | Portsmouth, NH Located in the town's historic Old City Hall, this 1,600 SF ground-floor suite offers one large corner office, two private offices, and two large open areas for reception or workstations.? Modern amenities, great visibility, vault-style storage, and instant access to downtown services, dining, and shops just steps away.?

Listed by Caleb Carter of CORE

MLS Number 5046886

• CommercialLease
• Lease 800
• Address 410 The Hill
• Year Built 1780

Great small office in downtown Portsmouth. Easy access to hotels, restaurants, retail, business community, and all downtown has to offer. Gross lease, private bath, on-site parking.

Listed by Robert Marchewka of Compass New England,LLC

MLS Number 5046715

• CommercialLease
• Lease 1350
• Address 456 Central Avenue
• Year Built 1932
• Acreage 0.52

Listed by Robert Marchewka of Compass New England,LLC

MLS Number 5046713

• CommercialLease
• Lease 750
• Address 456 Central Avenue
• Year Built 1932
• Acreage 0.52

Listed by Robert Marchewka of Compass New England,LLC

MLS Number 5046712

• CommercialLease
• Lease 750
• Address 456 Central Avenue
• Year Built 1932
• Acreage 0.52

Listed by Robert Marchewka of Compass New England,LLC

MLS Number 5046401

• CommercialLease
• Lease 1100
• Address 379 State Street

Welcome to the Abraham Shaw building located in downtown Portsmouth. This second level office space has many exquisite features. It has natural sunlight throughout most of the day, has its own private bath, cooled by central air, and has a comfortable shared waiting area. There is signage available on the exterior and in the interior of the building. Office is within walking distance to everything.

Listed by Candace Azotea of Carey Giampa,LLC/Portsmouth

MLS Number 5046396

• CommercialLease
• Lease 2800
• Address 137 Epping Road

Discover an exceptional retail opportunity at Exeter Village Shops with this soon-to-be fully renovated space. Featuring 1,072 +/- square feet of open retail area, along with a private office and a large bathroom, the versatile layout offers endless possibilities, making it ideal for various types of businesses. Large parking lot. Don't miss the chance to establish your presence in the vibrant Exeter community! $2,800 + utilities. Tenant responsible for gas, electricity & water/sewer.

Listed by Mollie Ruffner of Ruffner Real Estate,LLC

MLS Number 5045615

• CommercialLease
• Lease 700
• Address 456 Central Avenue
• Year Built 1932
• Acreage 0.52

Listed by Scott Rome and Robert Marchewka of Compass New England,LLC

MLS Number 5045535

• Commercial
• Address 79 Silver Street
• Year Built 1780
• Square Feet 3,851
• Acreage 0.54

The historic Ezra Green Home is one of the most architecturally significant properties in the City of Dover! With over half-acre and frontage on two main streets, this property offers tremendous potential for redevelopment and/or professional use. Given the high visibility and significant traffic count, this property would be ideal for Healthcare & Wellness uses such as Private Medical Practice, Dental Office, Chiropractic Office, Therapy/Counseling Center, Aesthetics & Med Spa, Physical Therapy Clinic, Holistic Health Center, or Speech & Occupational Therapy. Professional Services such as, Law Office, Accounting/CPA Firm, Architectural Firm, Engineering Firm, Real Estate Brokerage, Insurance Agency, Consulting Firm, or a Private Equity or Family Office. Tech & Creative uses could include IT Services Provider, Software Development Studio, Digital Marketing Agency, Design Studio, Video Production Studio or even a Coworking Hub with shared offices for remote professionals. Education & Training such as Tutoring or Learning Center, Corporate Training Facility or a Non-Profit Headquarters, may also work! Inside, you'll find stunning wide pine floors, a grand central staircase, intricate crown moldings and millwork, two wood-burning fireplaces, and original Indian shutters. Within walking distance to downtown with easy access to the Children's Museum of NH, parks, a variety of local shops and restaurants, as well as the Amtrak train station! Just 10 min to Portsmouth, 60 to Boston.

Listed by Jamieson Duston of Duston Leddy Real Estate

MLS Number 5045501

• CommercialLease
• Lease 170000
• Address 800 Lafayette Road
• Year Built 2011

Prime redevelopment opportunity at the former CITGO site on heavily traveled Lafayette Road in Portsmouth. This high-visibility location features two curb cuts, providing easy access from both directions of traffic. Highlights: o Excellent visibility and strong traffic exposure o Traffic counts of over 15,546± vehicles per day (2022); current estimates are 20,000± vehicles per day o Available 5/20/2026

Listed by Christian Stallkamp of The Boulos Company

MLS Number 5045102

• CommercialLease
• Lease 19
• Address 66 Third Street

Listed by Caitlin Burke of The Boulos Company

MLS Number 5045075

• Commercial
• Address 172 Hanover Street
• Year Built 1850
• Acreage 0.12
• Area NH-Rockingham

Incredible opportunity to own a high-visibility mixed-use asset in the heart of downtown Portsmouth. The property is anchored by a successful, long-term restaurant tenant with excellent street exposure and significant investment in the space. The second floor totals approximately 2,600 square feet and is approved for two residential units, each roughly 1,300 square feet. Both units are currently unfinished, offering immediate value-add potential for luxury rentals or condominium conversion. The basement, previously operated as a sports lounge, is also unfinished and presents strong potential for retail, studio, or other commercial uses depending on tenant needs. Located within Portsmouth's Downtown Overlay District and eligible for vertical expansion under the city's 55-foot zoning limit, this property presents long-term redevelopment upside. Surrounded by restaurants, hotels, public parking, and a nearby research facility, this location benefits from consistent foot traffic and strong investor appeal.

Listed by Edward Perez of Edward Perez